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This is a term applied to molecules that have both hydrophilic and hydrophobic moieties. Amphipathic: This substance inhibits prostaglandin H2 synthase-1 by blocking the channel through which the substrate, arachidonate, travels. Acetylsalicylic acid (aspirin) This is the region between the cell wall and cell membrane of prokaryotes. Periplasm the least polar of the amphipathic amino acids, but the thioether sulfur is an excellent ligand for many metal ions. Definitions amphipathic: having both polar and nonpolar character and therefore a tendency to form interfaces between hydrophobic and hydrophilic molecules. hydrophilic:tending to interact with water.Hydrophilic Phospholipids are the most abundant lipid in the plasma membrane Phospholipids are amphipathic molecules, containing hydrophobic and hydrophilic regions The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it © 2011 Pearson Education, Inc. 2 © 2011 Pearson Education, Inc.